On this date, the American molecular biologist Sol Spiegelman was born. He developed the technique of nucleic acid hybridization, which helped to lay the foundation for advances in recombinant DNA technology. He is also given credit for an experiment that produced a self-reproducing RNA chain of only 218 nucleotides, which was nick-named Spiegelman’s Monster.
- D.L. Kacian, D.R. Mills, F.R. Kramer, and S. Spiegelman, “A replicating RNA molecule suitable for a detailed analysis of extracellular evolution and replication,” Proceedings of the National Academy of Sciences U.S.A. 69(10): 3038–3042 (Oct. 1972).
- D.R. Mills, R.L. Peterson, and S. Spiegelman, “An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule,” Proceedings of the National Academy of Sciences U.S.A. 58(1): 217-224 (July 1967).